Homeopathy

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Template:Pp-vandalism Template:Infobox alternative medicine Template:Alternative medical systems Homeopathy (Template:IPAc-en) is a system of alternative medicine created in 1796 by Samuel Hahnemann, based on his doctrine of like cures like (similia similibus curentur), a claim that a substance that causes the symptoms of a disease in healthy people would cure similar symptoms in sick people.[1] Homeopathy is a pseudoscience – a belief that is incorrectly presented as scientific. Homeopathic preparations are not effective for treating any condition;[2][3][4][5] large-scale studies have found homeopathy to be no more effective than a placebo, suggesting that any positive feelings that follow treatment are only due to the placebo effect and normal recovery from illness.[6][7][8]

Hahnemann believed the underlying causes of disease were phenomena that he termed miasms, and that homeopathic preparations addressed these. The preparations are manufactured using a process of homeopathic dilution, in which a chosen substance is repeatedly diluted in alcohol or distilled water, each time with the containing vessel being bashed against an elastic material, (commonly a leather-bound book).[9] Dilution typically continues well past the point where no molecules of the original substance remain.[10] Homeopaths select homeopathics[11] by consulting reference books known as repertories, and by considering the totality of the patient's symptoms, personal traits, physical and psychological state, and life history.[12]

Homeopathy is not a plausible system of treatment, as its dogmas about how drugs, illness, the human body, liquids and solutions operate are contradicted by a wide range of discoveries across biology, psychology, physics and chemistry made in the two centuries since its invention.[7][13][14][15][16] Although some clinical trials produce positive results,[17][18] multiple systematic reviews have indicated that this is because of chance, flawed research methods, and reporting bias. Continued homeopathic practice, despite the evidence that it does not work, has been criticized as unethical because it discourages the use of effective treatments,[19] with the World Health Organisation warning against using homeopathy to try to treat severe diseases such as HIV and malaria.[20] The continued practice of homeopathy, despite a lack of evidence of efficacy,[6][7][21] has led to it being characterized within the scientific and medical communities as nonsense,[22] quackery,[4][23][24] and a sham.[25]

Assessments by the Australian National Health and Medical Research Council, the British National Health and Medical Research Council, and the Swiss Federal Health Office have each concluded that homeopathy is ineffective, and recommended against the practice receiving any further funding.[26][27]

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History

File:Beydeman Gomeopatiya vzir.jpg
1857 painting by Alexander Beydeman, showing historical figures and personifications of homeopathy observing the brutality of medicine of the 19th century

Historical context

Homeopaths claim that Hippocrates may have originated homeopathy around 400 BC, when he prescribed a small dose of mandrake root to treat mania, knowing it produces mania in much larger doses.[28] In the 16th century, the pioneer of pharmacology Paracelsus declared that small doses of "what makes a man ill also cures him".[29] Samuel Hahnemann (1755–1843) gave homeopathy its name and expanded its principles in the late 18th century.

In the late 18th and 19th centuries, mainstream medicine used methods like bloodletting and purging, and administered complex mixtures, such as Venice treacle, which was made from 64 substances including opium, myrrh, and viper's flesh.[30] These treatments often worsened symptoms and sometimes proved fatal.[31][32] Hahnemann rejected these practices – which had been extolled for centuries[33] – as irrational and inadvisable;[34] instead, he advocated the use of single drugs at lower doses and promoted an immaterial, vitalistic view of how living organisms function, believing that diseases have spiritual, as well as physical causes.[35]

Hahnemann's concept

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File:Samuel Hahnemann Monument, Scott Circle.jpg
Samuel Hahnemann Monument, Washington D.C. with "Similia Similibus Curentur" - Like cures Like.

The term "homeopathy" was coined by Hahnemann and first appeared in print in 1807.[36]

Hahnemann conceived of homeopathy while translating a medical treatise by the Scottish physician and chemist William Cullen into German. Being skeptical of Cullen's theory concerning cinchona's use for curing malaria, Hahnemann ingested some bark specifically to investigate what would happen. He experienced fever, shivering and joint pain: symptoms similar to those of malaria itself. From this, Hahnemann came to believe that all effective drugs produce symptoms in healthy individuals similar to those of the diseases that they treat, in accord with the "law of similars" that had been proposed by ancient physicians.[37] An account of the effects of eating cinchona bark noted by Oliver Wendell Holmes, and published in 1861, failed to reproduce the symptoms Hahnemann reported.[38]Template:Rp Hahnemann's law of similars is a postulate rather than a scientific law.[39] This led to the name "homeopathy", which comes from the Template:Lang-grc-gre hómoios, "-like" and Template:Lang páthos, "suffering")

Subsequent scientific work showed that cinchona cures malaria because it contains quinine, which kills the Plasmodium falciparum parasite that causes the disease; the mechanism of action is unrelated to Hahnemann's ideas.[40]

"Provings"

Hahnemann began to test what effects substances produced in humans, a procedure that would later become known as "homeopathic proving". These tests required subjects to test the effects of ingesting substances by clearly recording all of their symptoms as well as the ancillary conditions under which they appeared.[41] He published a collection of provings in 1805, and a second collection of 65 preparations appeared in his book, Materia Medica Pura, in 1810.[42]

Because Hahnemann believed that large doses of drugs that caused similar symptoms would only aggravate illness, he advocated extreme dilutions of the substances; he devised a technique for making dilutions that he believed would preserve a substance's therapeutic properties while removing its harmful effects.[10] Hahnemann believed that this process aroused and enhanced "the spirit-like medicinal powers of the crude substances".[43] He gathered and published a complete overview of his new medical system in his 1810 book, The Organon of the Healing Art, whose 6th edition, published in 1921, is still used by homeopaths today.[44]

Miasms and disease

File:LedumPalustre15CH.jpg
A homeopathic preparation made from marsh tea: the "15C" dilution shown here means the original solution was diluted to 1/1030 of its original strength. Given that there are many orders of magnitude fewer than 1030 molecules in the small sample, the likelihood that it contains even one molecule of the original herb is extremely low.

In The Organon of the Healing Art, Hahnemann introduced the concept of "miasms" as "infectious principles" underlying chronic disease.[45] Hahnemann associated each miasm with specific diseases, and thought that initial exposure to miasms causes local symptoms, such as skin or venereal diseases. If, however, these symptoms were suppressed by medication, the cause went deeper and began to manifest itself as diseases of the internal organs.[46] Homeopathy maintains that treating diseases by directly alleviating their symptoms, as is sometimes done in conventional medicine, is ineffective because all "disease can generally be traced to some latent, deep-seated, underlying chronic, or inherited tendency".[47] The underlying imputed miasm still remains, and deep-seated ailments can be corrected only by removing the deeper disturbance of the vital force.[48]

Hahnemann’s hypotheses for the direct or remote cause of all chronic diseases (miasms) originally presented only three, psora (the itch), syphilis (venereal disease) or sycosis (fig-wart disease).[49] Of these three the most important was psora (Greek for "itch"), described as being related to any itching diseases of the skin, supposed to be derived from suppressed scabies, and claimed to be the foundation of many further disease conditions. Hahnemann believed psora to be the cause of such diseases as epilepsy, cancer, jaundice, deafness, and cataracts.[50] Since Hahnemann's time, other miasms have been proposed, some replacing one or more of psora's proposed functions, including tuberculosis and cancer miasms.[46]

The law of susceptibility implies that a negative state of mind can attract hypothetical disease entities called "miasms" to invade the body and produce symptoms of diseases.[51] Hahnemann rejected the notion of a disease as a separate thing or invading entity, and insisted it was always part of the "living whole".[52] Hahnemann coined the expression "allopathic medicine", which was used to pejoratively refer to traditional Western medicine.[53]

Hahnemann's miasm theory remains disputed and controversial within homeopathy even in modern times. The theory of miasms has been criticized as an explanation developed by Hahnemann to preserve the system of homeopathy in the face of treatment failures, and for being inadequate to cover the many hundreds of sorts of diseases, as well as for failing to explain disease predispositions, as well as genetics, environmental factors, and the unique disease history of each patient.[54]Template:Rp

19th century: rise to popularity and early criticism

Homeopathy achieved its greatest popularity in the 19th century. It was introduced to the United States in 1825 by Hans Birch Gram, a student of Hahnemann.[55] The first homeopathic school in the US opened in 1835, and in 1844, the first US national medical association, the American Institute of Homeopathy, was established. Throughout the 19th century, dozens of homeopathic institutions appeared in Europe and the United States,[56] and by 1900, there were 22 homeopathic colleges and 15,000 practitioners in the United States.[57] Because medical practice of the time relied on ineffective and often dangerous treatments, patients of homeopaths often had better outcomes than those of the doctors of the time.[58] Homeopathic preparations, even if ineffective, would almost surely cause no harm, making the users of homeopathic preparations less likely to be killed by the treatment that was supposed to be helping them.[44] The relative success of homeopathy in the 19th century may have led to the abandonment of the ineffective and harmful treatments of bloodletting and purging and to have begun the move towards more effective, science-based medicine.[32] One reason for the growing popularity of homeopathy was its apparent success in treating people suffering from infectious disease epidemics.[59] During 19th-century epidemics of diseases such as cholera, death rates in homeopathic hospitals were often lower than in conventional hospitals, where the treatments used at the time were often harmful and did little or nothing to combat the diseases.[60]

From its inception, however, homeopathy was criticized by mainstream science. Sir John Forbes, physician to Queen Victoria, said in 1843 that the extremely small doses of homeopathy were regularly derided as useless, "an outrage to human reason".[61] James Young Simpson said in 1853 of the highly diluted drugs: "No poison, however strong or powerful, the billionth or decillionth of which would in the least degree affect a man or harm a fly."[62] 19th-century American physician and author Oliver Wendell Holmes, Sr. was also a vocal critic of homeopathy and published an essay in 1842 entitled Homœopathy and Its Kindred Delusions.[38] The members of the French Homeopathic Society observed in 1867 that some leading homeopathists of Europe not only were abandoning the practice of administering infinitesimal doses but were also no longer defending it.[63] The last school in the US exclusively teaching homeopathy closed in 1920.[44]

Revival in the 20th century

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According to Paul Ulrich Unschuld, the Nazi regime in Germany was fascinated by homeopathy, and spent large sums of money on researching its mechanisms, but without gaining a positive result. Unschuld further argues that homeopathy never subsequently took root in the United States, but remained more deeply established in European thinking.[64]

In the United States, the Food, Drug, and Cosmetic Act of 1938 (sponsored by Royal Copeland, a Senator from New York and homeopathic physician) recognized homeopathic preparations as drugs. In the 1950s, there were only 75 pure homeopaths practicing in the U.S.[65] However, by the mid to late 1970s, homeopathy made a significant comeback and sales of some homeopathic companies increased tenfold.[66] Some homeopaths give credit for the revival to Greek homeopath George Vithoulkas, who performed a "great deal of research to update the scenarios and refine the theories and practice of homeopathy", beginning in the 1970s,[67][68] but Ernst and Singh consider it to be linked to the rise of the New Age movement.[33] Whichever is correct, mainstream pharmacy chains recognized the business potential of selling homeopathic preparations.[69] The Food and Drug Administration held a hearing April 20 and 21, 2015, requesting public comment on regulation of homeopathic drugs.[70] The FDA cited the growth of sales of over the counter homeopathic medicines, $2.7 billion as of 2007, many labeled as "natural, safe, and effective".[71]

Bruce Hood has argued that the increased popularity of homeopathy in recent times may be due to the comparatively long consultations practitioners are willing to give their patients, and to an irrational preference for "natural" products which people think are the basis of homeopathic preparations.[72]

Preparations and treatment

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File:Rhustox.jpg
Homeopathic preparation Rhus toxicodendron, derived from poison ivy.
File:Homeo ingredients r87.jpg
a preparation made from D dilutions of dangerous materials like botulism, E-coli, thymus gland of unspecified origin, pneumonia, pseudomona, proteus, salmonella, scarlet fever, staph, strep and tuberculosis bacteria. Ethanol is listed as being redundantly diluted in alcohol.

Homeopathic preparations are referred to as "homeopathics"[11] or "remedies". Practitioners rely on two types of reference when prescribing: materia medica and repertories. A homeopathic materia medica is a collection of "drug pictures", organised alphabetically. These entries describe the symptom patterns associated with individual preparations. A homeopathic repertory is an index of disease symptoms that lists preparations associated with specific symptoms. In both cases different compilers may dispute particular inclusions.[73] The first symptomatic homeopathic materia medica was arranged by Hahnemann. The first homeopathic repertory was Georg Jahr's Symptomenkodex, published in German in 1835, and translated into English as the Repertory to the more Characteristic Symptoms of Materia Medica by Constantine Hering in 1838. This version was less focused on disease categories and would be the forerunner to later works by James Tyler Kent.[74][75] Repertories, in particular, may be very large.

Homeopathy uses animal, plant, mineral, and synthetic substances in its preparations, generally referring to them using Latin or faux-Latin names. Examples include arsenicum album (arsenic oxide), natrum muriaticum (sodium chloride or table salt), Lachesis muta (the venom of the bushmaster snake), opium, and thyroidinum (thyroid hormone).

Some homeopaths use so-called "nosodes" (from the Greek nosos, disease) made from diseased or pathological products such as fecal, urinary, and respiratory discharges, blood, and tissue.[74] Conversely, preparations made from "healthy" specimens are called "sarcodes".

Some modern homeopaths use preparations they call "imponderables" because they do not originate from a substance but some other phenomenon presumed to have been "captured" by alcohol or lactose. Examples include X-rays[76] and sunlight.[77]

Other minority practices include paper preparations, where the substance and dilution are written on pieces of paper and either pinned to the patients' clothing, put in their pockets, or placed under glasses of water that are then given to the patients, and the use of radionics to manufacture preparations. Such practices have been strongly criticised by classical homeopaths as unfounded, speculative, and verging upon magic and superstition.[78][79]

Preparation

File:Mortar2.jpg
Mortar and pestle used for grinding insoluble solids, such as platinum, into homeopathic preparations

Hahnemann found that undiluted doses caused reactions, sometimes dangerous ones, so specified that preparations be given at the lowest possible dose. He found that this reduced potency as well as side-effects, but formed the view that vigorous shaking and striking on an elastic surface – a process he termed Schütteln, translated as succussion – nullified this.[80] A common explanation for his settling on this process is said to be that he found preparations subjected to agitation in transit, such as in saddle bags or in a carriage, were more "potent".[54]Template:Rp Hahnemann had a saddle-maker construct a special wooden striking board covered in leather on one side and stuffed with horsehair.[81]Template:Rp Insoluble solids, such as granite, diamond, and platinum, are diluted by grinding them with lactose ("trituration").[54]Template:Rp

The process of dilution and succussion is termed "dynamisation" or "potentisation" by homeopaths.[9][82] In industrial manufacture this may be done by machine.

Serial dilution is achieved by taking an amount of the mixture and adding solvent, but the "Korsakovian" method may also be used, whereby the vessel in which the preparations are manufactured is emptied, refilled with solvent, and the volume of fluid adhering to the walls of the vessel is deemed sufficient for the new batch.[54]Template:Rp The Korsakovian method is sometimes referred to as K on the label of a homeopathic preparation, e.g. 200CK is a 200C preparation made using the Korsakovian method.[83][84]

Fluxion and radionics methods of preparation do not require succussion.[54]Template:Rp There are differences of opinion on the number and force of strikes, and some practitioners dispute the need for succussion at all while others reject the Korsakovian and other non-classical preparations. There are no laboratory assays and the importance and techniques for succussion cannot be determined with any certainty from the literature.[54]Template:Rp

Dilutions

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Three main logarithmic potency scales are in regular use in homeopathy. Hahnemann created the "centesimal" or "C scale", diluting a substance by a factor of 100 at each stage. The centesimal scale was favored by Hahnemann for most of his life.

A 2C dilution requires a substance to be diluted to one part in 100, and then some of that diluted solution diluted by a further factor of 100.

This works out to one part of the original substance in 10,000 parts of the solution.[85] A 6C dilution repeats this process six times, ending up with the original substance diluted by a factor of 100−6=10−12 (one part in one trillion or 1/1,000,000,000,000). Higher dilutions follow the same pattern.

In homeopathy, a solution that is more dilute is described as having a higher "potency", and more dilute substances are considered by homeopaths to be stronger and deeper-acting.[86] The end product is often so diluted as to be indistinguishable from the diluent (pure water, sugar or alcohol).[10][87][88] There is also a decimal potency scale (notated as "X" or "D") in which the preparation is diluted by a factor of 10 at each stage.[89]

Hahnemann advocated 30C dilutions for most purposes (that is, dilution by a factor of 1060).[9] Hahnemann regularly used potencies up to 300C but opined that "there must be a limit to the matter, it cannot go on indefinitely".[41]Template:Rp

In Hahnemann's time, it was reasonable to assume the preparations could be diluted indefinitely, as the concept of the atom or molecule as the smallest possible unit of a chemical substance was just beginning to be recognized.

The greatest dilution reasonably likely to contain even one molecule of the original substance is 12C.[90]

File:Arnica montana homéopathie zoom.jpg
This bottle is labelled Arnica montana (wolf's bane) D6, i.e. the nominal dilution is one part in a million (10-6).

Critics and advocates of homeopathy alike commonly attempt to illustrate the dilutions involved in homeopathy with analogies.[91] Hahnemann is reported to have joked that a suitable procedure to deal with an epidemic would be to empty a bottle of poison into Lake Geneva, if it could be succussed 60 times.[92][93] Another example given by a critic of homeopathy states that a 12C solution is equivalent to a "pinch of salt in both the North and South Atlantic Oceans",[92][93] which is approximately correct.[94] One-third of a drop of some original substance diluted into all the water on earth would produce a preparation with a concentration of about 13C.[91][95][96] A popular homeopathic treatment for the flu is a 200C dilution of duck liver, marketed under the name Oscillococcinum. As there are only about 1080 atoms in the entire observable universe, a dilution of one molecule in the observable universe would be about 40C. Oscillococcinum would thus require 10320 more universes to simply have one molecule in the final substance.[97] The high dilutions characteristically used are often considered to be the most controversial and implausible aspect of homeopathy.[98]

Not all homeopaths advocate high dilutions. Preparations at concentrations below 4X are considered an important part of homeopathic heritage.[99] Many of the early homeopaths were originally doctors and generally used lower dilutions such as "3X" or "6X", rarely going beyond "12X". The split between lower and higher dilutions followed ideological lines. Those favoring low dilutions stressed pathology and a stronger link to conventional medicine, while those favoring high dilutions emphasised vital force, miasms and a spiritual interpretation of disease.[100][101] Some products with such relatively lower dilutions continue to be sold, but like their counterparts, they have not been conclusively demonstrated to have any effect beyond that of a placebo.[102][103]

Provings

A homeopathic "proving" is the method by which the profile of a homeopathic preparation is determined.[104]

At first Hahnemann used undiluted doses for provings, but he later advocated provings with preparations at a 30C dilution,[9] and most modern provings are carried out using ultradilute preparations in which it is highly unlikely that any of the original molecules remain.[105] During the proving process, Hahnemann administered preparations to healthy volunteers, and the resulting symptoms were compiled by observers into a "drug picture".

The volunteers were observed for months at a time and made to keep extensive journals detailing all of their symptoms at specific times throughout the day. They were forbidden from consuming coffee, tea, spices, or wine for the duration of the experiment; playing chess was also prohibited because Hahnemann considered it to be "too exciting", though they were allowed to drink beer and encouraged to exercise in moderation.[106]

After the experiments were over, Hahnemann made the volunteers take an oath swearing that what they reported in their journals was the truth, at which time he would interrogate them extensively concerning their symptoms.

Provings are claimed to have been important in the development of the clinical trial, due to their early use of simple control groups, systematic and quantitative procedures, and some of the first application of statistics in medicine.[107] The lengthy records of self-experimentation by homeopaths have occasionally proven useful in the development of modern drugs: For example, evidence that nitroglycerin might be useful as a treatment for angina was discovered by looking through homeopathic provings, though homeopaths themselves never used it for that purpose at that time.[108] The first recorded provings were published by Hahnemann in his 1796 Essay on a New Principle.[109] His Fragmenta de Viribus (1805)[110] contained the results of 27 provings, and his 1810 Materia Medica Pura contained 65.[111] For James Tyler Kent's 1905 Lectures on Homoeopathic Materia Medica, 217 preparations underwent provings and newer substances are continually added to contemporary versions.

Though the proving process has superficial similarities with clinical trials, it is fundamentally different in that the process is subjective, not blinded, and modern provings are unlikely to use pharmacologically active levels of the substance under proving.[112] As early as 1842, Holmes noted the provings were impossibly vague, and the purported effect was not repeatable among different subjects.[38]

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Homeopathic consultation

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Homeopathic repertory by James Tyler Kent

Homeopaths generally begin with detailed examinations of their patients' histories, including questions regarding their physical, mental and emotional states, their life circumstances and any physical or emotional illnesses. The homeopath then attempts to translate this information into a complex formula of mental and physical symptoms, including likes, dislikes, innate predispositions and even body type.[113]

From these symptoms, the homeopath chooses how to treat the patient using materia medica and repertories. In classical homeopathy, the practitioner attempts to match a single preparation to the totality of symptoms (the simlilum), while "clinical homeopathy" involves combinations of preparations based on the various symptoms of an illness.[67]

Pills and active ingredients

File:DoseOscillococcinum.jpg
Homeopathic pills, homeopathic preparation oscillococcinum

Homeopathic pills are made from an inert substance (often sugars, typically lactose), upon which a drop of liquid homeopathic preparation is placed and allowed to evaporate.[114][115]

The process of homeopathic dilution results in no objectively detectable active ingredient in most cases, but some preparations (e.g. calendula and arnica creams) do contain pharmacologically active doses. One product, Zicam Cold Remedy, which was marketed as an "unapproved homeopathic" product,[116] contains two ingredients that are only "slightly" diluted: zinc acetate (2X = 1/100 dilution) and zinc gluconate (1X = 1/10 dilution),[116] which means both are present in a biologically active concentration strong enough to have caused some people to lose their sense of smell,[117] a condition termed anosmia. Zicam also listed several normal homeopathic potencies as "inactive ingredients", including galphimia glauca,[118] histamine dihydrochloride (homeopathic name, histaminum hydrochloricum),[119] luffa operculata,[120] and sulfur.

Related and minority treatments and practices

Isopathy

Isopathy is a therapy derived from homeopathy, invented by Johann Joseph Wilhelm Lux in the 1830s. Isopathy differs from homeopathy in general in that the preparations, known as "nosodes", are made up either from things that cause the disease or from products of the disease, such as pus.[74][121] Many so-called "homeopathic vaccines" are a form of isopathy.[122]

Flower preparations

Flower preparations can be produced by placing flowers in water and exposing them to sunlight. The most famous of these are the Bach flower remedies, which were developed by the physician and homeopath Edward Bach. Although the proponents of these preparations share homeopathy's vitalist world-view and the preparations are claimed to act through the same hypothetical "vital force" as homeopathy, the method of preparation is different. Bach flower preparations are manufactured in allegedly "gentler" ways such as placing flowers in bowls of sunlit water, and the preparations are not succussed.[123] There is no convincing scientific or clinical evidence for flower preparations being effective.[124]

Veterinary use

The idea of using homeopathy as a treatment for other animals, termed "veterinary homeopathy", dates back to the inception of homeopathy; Hahnemann himself wrote and spoke of the use of homeopathy in animals other than humans.[125] The FDA has not approved homeopathic products as veterinary medicine in the U.S. In the UK, veterinary surgeons who use homeopathy may belong to the Faculty of Homeopathy and/or to the British Association of Homeopathic Veterinary Surgeons. Animals may be treated only by qualified veterinary surgeons in the UK and some other countries. Internationally, the body that supports and represents homeopathic veterinarians is the International Association for Veterinary Homeopathy.

The use of homeopathy in veterinary medicine is controversial; the little existing research on the subject is not of a high enough scientific standard to provide reliable data on efficacy.[126][127] Other studies have also found that giving animals placebos can play active roles in influencing pet owners to believe in the effectiveness of the treatment when none exists.[126] The British Veterinary Association's position statement on alternative medicines says that it "cannot endorse" homeopathy,[128] and the Australian Veterinary Association includes it on its list of "ineffective therapies".[129]

The UK's Department for Environment, Food and Rural Affairs (Defra) has adopted a robust position against use of "alternative" pet preparations including homeopathy.[130]

Electrohomeopathy

Template:Main Electrohomeopathy is a treatment devised by Count Cesare Mattei (1809–1896), who proposed that different "colors" of electricity could be used to treat cancer. Popular in the late nineteenth century, electrohomeopathy has been described as "utter idiocy".[131]

Homeoprophylaxis

The use of homeopathy as a preventive for serious infectious diseases is especially controversial,[132] in the context of ill-founded public alarm over the safety of vaccines stoked by the anti-vaccination movement.[133] Promotion of homeopathic alternatives to vaccines has been characterised as dangerous, inappropriate and irresponsible.[134][135] In December 2014, Australian homeopathy supplier Homeopathy Plus! were found to have acted deceptively in promoting homeopathic alternatives to vaccines.[136]

Evidence and efficacy

The low concentration of homeopathic preparations, which often lack even a single molecule of the diluted substance,[114] has been the basis of questions about the effects of the preparations since the 19th century. Modern advocates of homeopathy have proposed a concept of "water memory", according to which water "remembers" the substances mixed in it, and transmits the effect of those substances when consumed. This concept is inconsistent with the current understanding of matter, and water memory has never been demonstrated to have any detectable effect, biological or otherwise.[137][138] Pharmacological research has found instead that stronger effects of an active ingredient come from higher, not lower doses.

James Randi and the 10:23 campaign groups have highlighted the lack of active ingredients in most homeopathic products by taking large 'overdoses'.[139] None of the hundreds of demonstrators in the UK, Australia, New Zealand, Canada and the US were injured and "no one was cured of anything, either".[139][140]

Outside of the alternative medicine community, scientists have long considered homeopathy a sham[25] or a pseudoscience,[2][3][4][5] and the mainstream medical community regards it as quackery.[4] There is an overall absence of sound statistical evidence of therapeutic efficacy, which is consistent with the lack of any biologically plausible pharmacological agent or mechanism.[6]

Abstract concepts within theoretical physics have been invoked to suggest explanations of how or why preparations might work, including quantum entanglement,[141] quantum nonlocality,[142] the theory of relativity and chaos theory. Contrariwise, quantum superposition has been invoked to explain why homeopathy does not work in double-blind trials.[143] However, the explanations are offered by nonspecialists within the field, and often include speculations that are incorrect in their application of the concepts and not supported by actual experiments.[54]Template:Rp Several of the key concepts of homeopathy conflict with fundamental concepts of physics and chemistry.[144] The use of quantum entanglement to explain homeopathy's purported effects is "patent nonsense", as entanglement is a delicate state which rarely lasts longer than a fraction of a second.[145] While entanglement may result in certain aspects of individual subatomic particles acquiring linked quantum states, this does not mean the particles will mirror or duplicate each other, nor cause health-improving transformations.[145]

Plausibility

The proposed mechanisms for homeopathy are precluded from having any effect by the laws of physics and physical chemistry.[16] The extreme dilutions used in homeopathic preparations usually leave none of the original substance in the final product.

A number of speculative mechanisms have been advanced to counter this, the most widely discussed being water memory, though this is now considered erroneous since short-range order in water only persists for about 1 picosecond.[146][147][148] No evidence of stable clusters of water molecules was found when homeopathic preparations were studied using nuclear magnetic resonance,[149] and many other physical experiments in homeopathy have been found to be of low methodological quality, which precludes any meaningful conclusion.[150] Existence of a pharmacological effect in the absence of any true active ingredient is inconsistent with the law of mass action and the observed dose-response relationships characteristic of therapeutic drugs[151] (whereas placebo effects are non-specific and unrelated to pharmacological activity[152]).

Homeopaths contend that their methods produce a therapeutically active preparation, selectively including only the intended substance, though critics note that any water will have been in contact with millions of different substances throughout its history, and homeopaths have not been able to account for a reason why only the selected homeopathic substance would be a special case in their process.[3] For comparison, ISO 3696: 1987 defines a standard for water used in laboratory analysis; this allows for a contaminant level of ten parts per billion, 4C in homeopathic notation. This water may not be kept in glass as contaminants will leach out into the water.[153]

Practitioners of homeopathy hold that higher dilutions―described as being of higher potency―produce stronger medicinal effects. This idea is also inconsistent with observed dose-response relationships, where effects are dependent on the concentration of the active ingredient in the body.[151] This dose-response relationship has been confirmed in myriad experiments on organisms as diverse as nematodes,[154] rats,[155] and humans.[156] Some homeopaths contend that the phenomenon of hormesis may support the idea of dilution increasing potency,[157][158] but the dose-response relationship outside the zone of hormesis declines with dilution as normal, and nonlinear pharmacological effects do not provide any credible support for homeopathy.[159]

Physicist Robert L. Park, former executive director of the American Physical Society, is quoted as saying,

"since the least amount of a substance in a solution is one molecule, a 30C solution would have to have at least one molecule of the original substance dissolved in a minimum of 1,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000 [or 1060] molecules of water. This would require a container more than 30,000,000,000 times the size of the Earth."[160]

Park is also quoted as saying that, "to expect to get even one molecule of the 'medicinal' substance allegedly present in 30X pills, it would be necessary to take some two billion of them, which would total about a thousand tons of lactose plus whatever impurities the lactose contained".[160]

The laws of chemistry state that there is a limit to the dilution that can be made without losing the original substance altogether.[114] This limit, which is related to Avogadro's number, is roughly equal to homeopathic dilutions of 12C or 24X (1 part in 1024).[91][160][161]

Scientific tests run by both the BBC's Horizon and ABC's 20/20 programs were unable to differentiate homeopathic dilutions from water, even when using tests suggested by homeopaths themselves.[162][163]

Efficacy

File:Hepar.jpg
Old bottle of Hepar sulph made from calcium sulfide

No individual preparation has been unambiguously shown by research to be different from placebo.[6] The methodological quality of the primary research was generally low, with such problems as weaknesses in study design and reporting, small sample size, and selection bias. Since better quality trials have become available, the evidence for efficacy of homeopathy preparations has diminished; the highest-quality trials indicate that the preparations themselves exert no intrinsic effect.[18][54]Template:Rp[164] A review conducted in 2010 of all the pertinent studies of "best evidence" produced by the Cochrane Collaboration concluded that "the most reliable evidence – that produced by Cochrane reviews – fails to demonstrate that homeopathic medicines have effects beyond placebo."[165]

Government level reviews

Government-level reviews have been conducted in recent years by Switzerland (2005), the United Kingdom (2009) and Australia (2015).

The Swiss programme for the evaluation of complementary medicine (PEK) resulted in the peer-reviewed Shang publication (see Systematic reviews and meta-analyses of efficacy) and a controversial competing analysis[166] by homeopaths and advocates led by Gudrun Bornhöft and Peter Matthiessen, which has misleadingly been presented as a Swiss government report by homeopathy proponents, a claim that has been repudiated by the Swiss Federal Office of Public Health.[167] The Swiss Government terminated reimbursement, though it was subsequently reinstated after a political campaign and referendum for a further six-year trial period.[168]

The United Kingdom's House of Commons Science and Technology Committee sought written evidence and submissions from concerned parties[169][170] and, following a review of all submissions, concluded that there was no compelling evidence of effect other than placebo and recommended that the Medicines and Healthcare products Regulatory Agency (MHRA) should not allow homeopathic product labels to make medical claims, that homeopathic products should no longer be licensed by the MHRA, as they are not medicines, and that further clinical trials of homeopathy could not be justified.[15] They recommended that funding of homeopathic hospitals should not continue, and NHS doctors should not refer patients to homeopaths.[171] The Secretary of State for Health deferred to local NHS on funding homeopathy, in the name of patient choice.[172] By February 2011 only one third of primary care trusts still funded homeopathy.[173] By 2012, no British universities offered homeopathy courses.[174]

The Australian National Health and Medical Research Council completed a comprehensive review of the effectiveness of homeopathic preparations in 2015, in which it concluded that "there were no health conditions for which there was reliable evidence that homeopathy was effective. No good-quality, well-designed studies with enough participants for a meaningful result reported either that homeopathy caused greater health improvements than placebo, or caused health improvements equal to those of another treatment."[175]

Publication bias and other methodological issues

Template:Further The fact that individual randomized controlled trials have given positive results is not in contradiction with an overall lack of statistical evidence of efficacy. A small proportion of randomized controlled trials inevitably provide false-positive outcomes due to the play of chance: a "statistically significant" positive outcome is commonly adjudicated when the probability of it being due to chance rather than a real effect is no more than 5%―a level at which about 1 in 20 tests can be expected to show a positive result in the absence of any therapeutic effect.[176] Furthermore, trials of low methodological quality (i.e. ones which have been inappropriately designed, conducted or reported) are prone to give misleading results. In a systematic review of the methodological quality of randomized trials in three branches of alternative medicine, Linde et al. highlighted major weaknesses in the homeopathy sector, including poor randomization.[177] A separate 2001 systematic review that assessed the quality of clinical trials of homeopathy found that such trials were generally of lower quality than trials of conventional medicine.[178]

A related issue is publication bias: researchers are more likely to submit trials that report a positive finding for publication, and journals prefer to publish positive results.[179][180][181][182] Publication bias has been particularly marked in alternative medicine journals, where few of the published articles (just 5% during the year 2000) tend to report null results.[183] Regarding the way in which homeopathy is represented in the medical literature, a systematic review found signs of bias in the publications of clinical trials (towards negative representation in mainstream medical journals, and vice versa in alternative medicine journals), but not in reviews.[18]

Positive results are much more likely to be false if the prior probability of the claim under test is low.[182]

Systematic reviews and meta-analyses of efficacy

Both meta-analyses, which statistically combine the results of several randomized controlled trials, and other systematic reviews of the literature are essential tools to summarize evidence of therapeutic efficacy.[184] Early systematic reviews and meta-analyses of trials evaluating the efficacy of homeopathic preparations in comparison with placebo more often tended to generate positive results, but appeared unconvincing overall.[185] In particular, reports of three large meta-analyses warned readers that firm conclusions could not be reached, largely due to methodological flaws in the primary studies and the difficulty in controlling for publication bias.[17][21][186] The positive finding of one of the most prominent of the early meta-analyses, published in The Lancet in 1997 by Linde et al.,[186] was later reframed by the same research team, who wrote:

The evidence of bias [in the primary studies] weakens the findings of our original meta-analysis. Since we completed our literature search in 1995, a considerable number of new homeopathy trials have been published. The fact that a number of the new high-quality trials ... have negative results, and a recent update of our review for the most "original" subtype of homeopathy (classical or individualized homeopathy), seem to confirm the finding that more rigorous trials have less-promising results. It seems, therefore, likely that our meta-analysis at least overestimated the effects of homeopathic treatments.[164]

Subsequent work by John Ioannidis and others has shown that for treatments with no prior plausibility, the chances of a positive result being a false positive are much higher, and that any result not consistent with the null hypothesis should be assumed to be a false positive.[182][187]

In 2002, a systematic review of the available systematic reviews confirmed that higher-quality trials tended to have less positive results, and found no convincing evidence that any homeopathic preparation exerts clinical effects different from placebo.[6]

In 2005, The Lancet medical journal published a meta-analysis of 110 placebo-controlled homeopathy trials and 110 matched medical trials based upon the Swiss government's Program for Evaluating Complementary Medicine, or PEK. The study concluded that its findings were "compatible with the notion that the clinical effects of homeopathy are placebo effects".[7] This was accompanied by an editorial pronouncing "The end of homoeopathy",[188] which was denounced by the homeopath Peter Fisher.[189]

Other meta-analyses include homeopathic treatments to reduce cancer therapy side-effects following radiotherapy and chemotherapy,[190] allergic rhinitis,[191] attention-deficit hyperactivity disorder and childhood diarrhea, adenoid vegetation, asthma, upper respiratory tract infection in children,[192] insomnia,[193] fibromyalgia,[194] psychiatric conditions[195] and Cochrane Library reviews of homeopathic treatments for asthma,[196] dementia,[197] attention-deficit hyperactivity disorder,[198] induction of labor,[199] and irritable bowel syndrome.[200] Other reviews covered osteoarthritis,[201] migraines[202] delayed-onset muscle soreness,[67] or eczema[203] and other dermatological conditions.[204]

The results of these reviews are generally negative or only weakly positive, and reviewers consistently report the poor quality of trials. The finding of Linde et. al. that more rigorous studies produce less positive results is supported in several and contradicted by none.

Some clinical trials have tested individualized homeopathy, and there have been reviews of this, specifically. A 1998 review[205] found 32 trials that met their inclusion criteria, 19 of which were placebo-controlled and provided enough data for meta-analysis. These 19 studies showed a pooled odds ratio of 1.17 to 2.23 in favor of individualized homeopathy over the placebo, but no difference was seen when the analysis was restricted to the methodologically best trials. The authors concluded that "the results of the available randomized trials suggest that individualized homeopathy has an effect over placebo. The evidence, however, is not convincing because of methodological shortcomings and inconsistencies." Jay Shelton, author of a book on homeopathy, has stated that the claim assumes without evidence that classical, individualized homeopathy works better than nonclassical variations.[54]Template:Rp A systematic review and meta-analysis of trials of individualised homeopathy published in December 2014 concluded that individualised homeopathy may have small effects, but that caution was needed in interpreting the results because of study quality issues – no study included was assessed as being at low risk of bias.[206]

Statements by major medical organisations

Health organisations such as the UK's National Health Service,[207] the American Medical Association,[208] the FASEB,[148] and the National Health and Medical Research Council of Australia,[209] have issued statements of their conclusion that there is "no good-quality evidence that homeopathy is effective as a treatment for any health condition".[207] In 2009, World Health Organization official Mario Raviglione cricitized the use of homeopathy to treat tuberculosis; similarly, another WHO spokesperson argued there was no evidence homeopathy would be an effective treatment for diarrhea.[210]

The American College of Medical Toxicology and the American Academy of Clinical Toxicology recommend that no one use homeopathic treatment for disease or as a preventive health measure.[211] These organizations report that no evidence exists that homeopathic treatment is effective, but that there is evidence that using these treatments produces harm and can bring indirect health risks by delaying conventional treatment.[211]

Explanations of perceived effects

Science offers a variety of explanations for how homeopathy may appear to cure diseases or alleviate symptoms even though the preparations themselves are inert:[54]Template:Rp

  • The placebo effect – the intensive consultation process and expectations for the homeopathic preparations may cause the effect.
  • Therapeutic effect of the consultation – the care, concern, and reassurance a patient experiences when opening up to a compassionate caregiver can have a positive effect on the patient's well-being.[212]
  • Unassisted natural healing – time and the body's ability to heal without assistance can eliminate many diseases of their own accord.
  • Unrecognized treatments – an unrelated food, exercise, environmental agent, or treatment for a different ailment, may have occurred.
  • Regression toward the mean – since many diseases or conditions are cyclical, symptoms vary over time and patients tend to seek care when discomfort is greatest; they may feel better anyway but because of the timing of the visit to the homeopath they attribute improvement to the preparation taken.
  • Non-homeopathic treatment – patients may also receive standard medical care at the same time as homeopathic treatment, and the former is responsible for improvement.
  • Cessation of unpleasant treatment – often homeopaths recommend patients stop getting medical treatment such as surgery or drugs, which can cause unpleasant side-effects; improvements are attributed to homeopathy when the actual cause is the cessation of the treatment causing side-effects in the first place, but the underlying disease remains untreated and still dangerous to the patient.

Purported effects in other biological systems

File:1belladonna.jpg
Old homeopathic belladonna preparation.

While some articles have suggested that homeopathic solutions of high dilution can have statistically significant effects on organic processes including the growth of grain,[213] histamine release by leukocytes,[214] and enzyme reactions, such evidence is disputed since attempts to replicate them have failed.[215][216][217][218][219][220] A 2007 systematic review of high-dilution experiments found that none of the experiments with positive results could be reproduced by all investigators.[221]

In 1987, French immunologist Jacques Benveniste submitted a paper to the journal Nature while working at INSERM. The paper purported to have discovered that basophils, a type of white blood cell, released histamine when exposed to a homeopathic dilution of anti-immunoglobulin E antibody. The journal editors, skeptical of the results, requested that the study be replicated in a separate laboratory. Upon replication in four separate laboratories the study was published. Still sceptical of the findings, Nature assembled an independent investigative team to determine the accuracy of the research, consisting of Nature editor and physicist Sir John Maddox, American scientific fraud investigator and chemist Walter Stewart, and sceptic James Randi. After investigating the findings and methodology of the experiment, the team found that the experiments were "statistically ill-controlled", "interpretation has been clouded by the exclusion of measurements in conflict with the claim", and concluded, "We believe that experimental data have been uncritically assessed and their imperfections inadequately reported."[138][222][223] James Randi stated that he doubted that there had been any conscious fraud, but that the researchers had allowed "wishful thinking" to influence their interpretation of the data.[222]

In 2001 and 2004, Madeleine Ennis published a number of studies which reported that homeopathic dilutions of histamine exerted an effect on the activity of basophils.[224][225] In response to the first of these studies, Horizon aired a program in which British scientists attempted to replicate Ennis' results; they were unable to do so.[226]

Ethics and safety

The provision of homeopathic preparations has been described as unethical.[19] Michael Baum, Professor Emeritus of Surgery and visiting Professor of Medical Humanities at University College London (UCL), has described homoeopathy as a "cruel deception".[227]

Edzard Ernst, the first Professor of Complementary Medicine in the United Kingdom and a former homeopathic practitioner,[228][229][230] has expressed his concerns about pharmacists who violate their ethical code by failing to provide customers with "necessary and relevant information" about the true nature of the homeopathic products they advertise and sell:

"My plea is simply for honesty. Let people buy what they want, but tell them the truth about what they are buying. These treatments are biologically implausible and the clinical tests have shown they don't do anything at all in human beings. The argument that this information is not relevant or important for customers is quite simply ridiculous."[231]

Patients who choose to use homeopathy rather than evidence-based medicine risk missing timely diagnosis and effective treatment of serious conditions such as cancer.[192][232]

In 2013 the UK Advertising Standards Authority concluded that the Society of Homeopaths were targeting vulnerable ill people and discouraging the use of essential medical treatment while making misleading claims of efficacy for homeopathic products.[233]

In 2015 the Federal Court of Australia imposed penalties on a homeopathic company, Homeopathy Plus! Pty Ltd and its director, for making false or misleading statements about the efficacy of the whooping cough vaccine and homeopathic remedies as an alternative to the whooping cough vaccine, in breach of the Australian Consumer Law. [234]

Adverse effects

Some homeopathic preparations involve poisons such as Belladonna, arsenic, and poison ivy, which are highly diluted in the homeopathic preparation. In rare cases the original ingredients are present at detectable levels. This may be due to improper preparation or intentional low dilution. Serious adverse effects such as seizures and death have been reported or associated with some homeopathic preparations.[235][236] Instances of arsenic poisoning have occurred after use of arsenic-containing homeopathic preparations.[237] Zicam Cold remedy Nasal Gel, which contains 2X (1:100) zinc gluconate, reportedly caused a small percentage of users to lose their sense of smell;[238] 340 cases were settled out of court in 2006 for Template:Nowrap.[239] In 2009, the FDA advised consumers to stop using three discontinued cold remedy Zicam products because it could cause permanent damage to users' sense of smell.[240] Zicam was launched without a New Drug Application (NDA) under a provision in the FDA's Compliance Policy Guide called "Conditions under which homeopathic drugs may be marketed" (CPG 7132.15), but the FDA warned Matrixx Initiatives, its manufacturer, via a Warning Letter that this policy does not apply when there is a health risk to consumers.[241]

A 2000 review by homeopaths reported that homeopathic preparations are "unlikely to provoke severe adverse reactions".[242] In 2012, a systematic review evaluating evidence of homeopathy's possible adverse effects concluded that "homeopathy has the potential to harm patients and consumers in both direct and indirect ways".[235] One of the reviewers, Edzard Ernst, supplemented the article on his blog, writing: "I have said it often and I say it again: if used as an alternative to an effective cure, even the most 'harmless' treatment can become life-threatening."[243]

Lack of efficacy

The lack of convincing scientific evidence supporting its efficacy[244] and its use of preparations without active ingredients have led to characterizations as pseudoscience and quackery,[245][246][247][248] or, in the words of a 1998 medical review, "placebo therapy at best and quackery at worst".[249] The Chief Medical Officer for England, Dame Sally Davies, has stated that homeopathic preparations are "rubbish" and do not serve as anything more than placebos.[250] Jack Killen, acting deputy director of the National Center for Complementary and Alternative Medicine, says homeopathy "goes beyond current understanding of chemistry and physics". He adds: "There is, to my knowledge, no condition for which homeopathy has been proven to be an effective treatment."[244] Ben Goldacre says that homeopaths who misrepresent scientific evidence to a scientifically illiterate public, have "... walled themselves off from academic medicine, and critique has been all too often met with avoidance rather than argument".[183] Homeopaths often prefer to ignore meta-analyses in favour of cherry picked positive results, such as by promoting a particular observational study (one which Goldacre describes as "little more than a customer-satisfaction survey") as if it were more informative than a series of randomized controlled trials.[183]

Referring specifically to homeopathy, the British House of Commons Science and Technology Committee has stated:

Template:Quote

Template:Quote

The National Center for Complementary and Alternative Medicine of the United States' National Institutes of Health states:

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Ben Goldacre noted that in the early days of homeopathy, when medicine was dogmatic and frequently worse than doing nothing, homeopathy at least failed to make matters worse:

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In lieu of standard medical treatment

On clinical grounds, patients who choose to use homeopathy in preference to normal medicine risk missing timely diagnosis and effective treatment, thereby worsening the outcomes of serious conditions.[192][232][251][252] Critics of homeopathy have cited individual cases of patients of homeopathy failing to receive proper treatment for diseases that could have been easily diagnosed and managed with conventional medicine and who have died as a result,[253][254] and the "marketing practice" of criticizing and downplaying the effectiveness of mainstream medicine.[183][254] Homeopaths claim that use of conventional medicines will "push the disease deeper" and cause more serious conditions, a process referred to as "suppression".[255] Some homeopaths (particularly those who are non-physicians) advise their patients against immunisation.[251][256][257] Some homeopaths suggest that vaccines be replaced with homeopathic "nosodes", created from biological materials such as pus, diseased tissue, bacilli from sputum or (in the case of "bowel nosodes") feces.[258] While Hahnemann was opposed to such preparations, modern homeopaths often use them although there is no evidence to indicate they have any beneficial effects.[259][260] Cases of homeopaths advising against the use of anti-malarial drugs have been identified.[252][261][262] This puts visitors to the tropics who take this advice in severe danger, since homeopathic preparations are completely ineffective against the malaria parasite.[252][261][262][263] Also, in one case in 2004, a homeopath instructed one of her patients to stop taking conventional medication for a heart condition, advising her on 22 June 2004 to "Stop ALL medications including homeopathic", advising her on or around 20 August that she no longer needed to take her heart medication, and adding on 23 August, "She just cannot take ANY drugs – I have suggested some homeopathic remedies ... I feel confident that if she follows the advice she will regain her health." The patient was admitted to hospital the next day, and died eight days later, the final diagnosis being "acute heart failure due to treatment discontinuation".[264][265]

In 1978, Anthony Campbell, then a consultant physician at the Royal London Homeopathic Hospital, criticised statements by George Vithoulkas claiming that syphilis, when treated with antibiotics, would develop into secondary and tertiary syphilis with involvement of the central nervous system, saying that "The unfortunate layman might well be misled by Vithoulkas' rhetoric into refusing orthodox treatment".[266] Vithoulkas' claims echo the idea that treating a disease with external medication used to treat the symptoms would only drive it deeper into the body and conflict with scientific studies, which indicate that penicillin treatment produces a complete cure of syphilis in more than 90% of cases.[267]

A 2006 review by W. Steven Pray of the College of Pharmacy at Southwestern Oklahoma State University recommends that pharmacy colleges include a required course in unproven medications and therapies, that ethical dilemmas inherent in recommending products lacking proven safety and efficacy data be discussed, and that students should be taught where unproven systems such as homeopathy depart from evidence-based medicine.[268]

In an article entitled "Should We Maintain an Open Mind about Homeopathy?"[269] published in the American Journal of Medicine, Michael Baum and Edzard ErnstTemplate:Spaced ndashwriting to other physiciansTemplate:Spaced ndashwrote that "Homeopathy is among the worst examples of faith-based medicine... These axioms [of homeopathy] are not only out of line with scientific facts but also directly opposed to them. If homeopathy is correct, much of physics, chemistry, and pharmacology must be incorrect...".

In 2013, Mark Walport, the UK Government Chief Scientific Adviser and head of the Government Office for Science, had this to say: "My view scientifically is absolutely clear: homoeopathy is nonsense, it is non-science. My advice to ministers is clear: that there is no science in homoeopathy. The most it can have is a placebo effect – it is then a political decision whether they spend money on it or not."[270] His predecessor, John Beddington, referring to his views on homeopathy being "fundamentally ignored" by the Government, said: "The only one [view being ignored] I could think of was homoeopathy, which is mad. It has no underpinning of scientific basis. In fact all the science points to the fact that it is not at all sensible. The clear evidence is saying this is wrong, but homoeopathy is still used on the NHS."[271]

Regulation and prevalence

Template:Main

File:Bristol Homeopathic.jpg
Hampton House, the former site of Bristol Homeopathic Hospital,one of three Homeopathic Hospitals in NHS.[15]

Homeopathy is fairly common in some countries while being uncommon in others; is highly regulated in some countries and mostly unregulated in others. It is practised worldwide and professional qualifications and licences are needed in most countries.[272] In some countries, there are no specific legal regulations concerning the use of homeopathy, while in others, licences or degrees in conventional medicine from accredited universities are required. In Germany, to become a homeopathic physician, one must attend a three-year training program, while France, Austria and Denmark mandate licences to diagnose any illness or dispense of any product whose purpose is to treat any illness.[272]

Some homeopathic treatment is covered by the public health service of several European countries, including France, the United Kingdom and Luxembourg. In other countries, such as Belgium, homeopathy is not covered. In Austria, the public health service requires scientific proof of effectiveness in order to reimburse medical treatments and homeopathy is listed as not reimbursable,[273] but exceptions can be made;[274] private health insurance policies sometimes include homeopathic treatment.[272] The Swiss government, after a 5-year trial, withdrew coverage of homeopathy and four other complementary treatments in 2005, stating that they did not meet efficacy and cost-effectiveness criteria,[188] but following a referendum in 2009 the five therapies have been reinstated for a further 6-year trial period from 2012.[275]

File:India - Varanasi pharmacy - 0830.jpg
Homeopathics at a homeopathic pharmacy in Varanasi, India.

The Indian government recognises homeopathy as one of its national systems of medicine;[276] it has established AYUSH or the Department of Ayurveda, Yoga and Naturopathy, Unani, Siddha and Homoeopathy under the Ministry of Health & Family Welfare.[277] The south Indian state of Kerala also gives the final nod for AYUSH department where homeopathy and Ayurveda are the main streams along with Sidha, Unani and Yoga.[278] The Central Council of Homoeopathy was established in 1973 to monitor higher education in homeopathy, and National Institute of Homoeopathy in 1975.[279] A minimum of a recognised diploma in homeopathy and registration on a state register or the Central Register of Homoeopathy is required to practice homeopathy in India.[280]

Public opposition

In the April 1997 edition of FDA Consumer, William T. Jarvis, the President of the National Council Against Health Fraud, said "Homeopathy is a fraud perpetrated on the public with the government's blessing, thanks to the abuse of political power of Sen. Royal S. Copeland [chief sponsor of the 1938 Food, Drug, and Cosmetic Act]."[281]

Mock "overdosing" on homeopathic preparations by individuals or groups in "mass suicides" have become more popular since James Randi began taking entire bottles of homeopathic sleeping pills before giving lectures.[282][283][284][285] In 2010 The Merseyside Skeptics Society from the United Kingdom launched the 10:23 campaign, encouraging groups to publicly overdose as groups. In 2011 the 10:23 campaign expanded and saw sixty-nine groups participate; fifty-four submitted videos.[286] In April 2012, at the Berkeley SkeptiCal conference, over 100 people participated in a mass overdose, taking coffea cruda, which is supposed to treat sleeplessness.[287][288]

In 2011, the non-profit, educational organizations Center for Inquiry (CFI) and the associated Committee for Skeptical Inquiry (CSI) have petitioned the U.S. Food and Drug Administration (FDA) to initiate 'rulemaking that would require all over-the-counter homeopathic drugs to meet the same standards of effectiveness as non-homeopathic drugs' and 'to place warning labels on homeopathic drugs until such time as they are shown to be effective'. In a separate petition, CFI and CSI request FDA to issue warning letters to Boiron, maker of Oscillococcinum, regarding their marketing tactic and criticize Boiron for misleading labeling and advertising of Oscillococcinum.[289] CFI in Canada is calling for persons that feel they were harmed by homeopathic products to contact them.[290]

In August 2011, a class action lawsuit was filed against Boiron on behalf of "all California residents who purchased Oscillo at any time within the past four years".[291] The lawsuit charged that it "is nothing more than a sugar pill", "despite falsely advertising that it contains an active ingredient known to treat flu symptoms".[292] In March 2012, Boiron agreed to spend up to $12 million to settle the claims of falsely advertising the benefits of its homeopathic preparations.[293]

In July 2012, CBC News reporter Erica Johnson for Marketplace conducted an investigation on the homeopathy industry in Canada; her findings were that it is "based on flawed science and some loopy thinking". Center for Inquiry (CFI) Vancouver skeptics participated in a mass overdose outside an emergency room in Vancouver, B.C., taking entire bottles of "medications" that should have made them sleepy, nauseous or dead; after 45 minutes of observation no ill effects were felt. Johnson asked homeopaths and company representatives about cures for cancer and vaccine claims. All reported positive results but none could offer any science backing up their statements, only that "it works". Johnson was unable to find any evidence that homeopathic preparations contain any active ingredient. Analysis performed at the University of Toronto's chemistry department found that the active ingredient is so small "it is equivalent to 5 billion times less than the amount of aspirin ... in a single pellet". Belladonna and ipecac "would be indistinguishable from each other in a blind test".[294][295]

Following a threat of legal action by the Good Thinking Society campaign group, the British government has stated that the Department of Health will hold a consultation in 2016 regarding whether homeopathic treatments should be added to the NHS treatments blacklist (officially, Schedule 1 of the National Health Service (General Medical Services Contracts) (Prescription of Drugs etc.) Regulations 2004), that specifies a blacklist of medicines not to be prescribed under the NHS.[296][297][298]

United States Food and Drug Administration (FDA) 2015 hearing

On April 20–21, 2015, the FDA held a hearing on homeopathic product regulation. Invitees representing the scientific and medical community, and various pro-homeopathy stakeholders, gave testimonials on homeopathic products and the regulatory role played by the FDA.[299] Michael de Dora, a representative from the Center for Inquiry (CFI), on behalf of the organization and dozens of doctors and scientists associated with CFI and the Committee for Skeptical Inquiry (CSI) gave a testimonial which summarized the basis of the organization's objection to homeopathic products, the harm done to the general public and proposed regulatory actions:[300]

The CFI testimonial stated that the principle of homeopathy is at complete odds with the basic principle of modern biology, chemistry and physics and that decades of scientific examination of homeopathic products shows that there is no evidence that it is effective in treating illnesses other than acting as a placebo. Further, it noted a 2012 report by the American Association of Poison Control Centers which listed 10,311 reported cases of poison exposure related to homeopathic agents, among which 8,788 cases were attributed to young children five years of age or younger,[301] as well as examples of harm – including deaths – caused to patients who relied on homeopathics instead of proven medical treatment.[300][302]

The CFI urged the FDA to announce and implement strict guidelines that 'require all homeopathic products meet the same standards as non-homeopathic drugs', arguing that the consumers can only have true freedom of choice (an often used argument from the homeopathy proponents) if they are fully informed on the choices. CFI proposed that the FDA take these three steps:

  1. Testing for homeopathic products The FDA will mandate that all homeopathic products on the market to perform and pass safety and efficacy tests equivalent to those required of non-homeopathic drugs.
  2. Labeling for homeopathic products To avert misleading label that the product is regulated by the FDA, all homeopathic products will be required to have prominent labels stating: 1) the products claimed active ingredients in plain English, and 2) the product has not been evaluated by the FDA for either safety or effectiveness.
  3. Regular consumer warnings Encouraged by the FDA's recent warning of the ineffectiveness of homeopathic products, CFI urged the FDA to issue regular warning to the consumers in addition to warning during public health crises and outbreaks.[300]

Official conclusions and recommendations

In March 2015, the National Health and Medical Research Council of Australia issued the following conclusions and recommendations:[175]

  • There is no reliable evidence that homeopathy is effective for treating health conditions.
  • Homeopathy should not be used to treat health conditions that are chronic, serious, or could become serious.
  • People who choose homeopathy may put their health at risk if they reject or delay treatments for which there is good evidence for safety and effectiveness.
  • People who are considering whether to use homeopathy should first get advice from a registered health practitioner. Those who use homeopathy should tell their health practitioner, and should keep taking any prescribed treatments.

See also

References

  1. Template:Cite book Translator: Charles H. Devrient, Esq.
  2. 2.0 2.1 Template:Cite book
  3. 3.0 3.1 3.2 Template:Cite journal
  4. 4.0 4.1 4.2 4.3 Template:Cite book
  5. 5.0 5.1 Template:Cite book
  6. 6.0 6.1 6.2 6.3 6.4 Template:Cite journal
  7. 7.0 7.1 7.2 7.3 Shang, Aijing; Karin Huwiler-Müntener & Linda Nartey et al. (2005), "Are the clinical effects of homoeopathy placebo effects? Comparative study of placebo-controlled trials of homoeopathy and allopathy", The Lancet 366 (9487): 726–732, DOI:10.1016/S0140-6736(05)67177-2
  8. Cite error: Invalid <ref> tag; no text was provided for refs named inquiry_4504
  9. 9.0 9.1 9.2 9.3 Hahnemann S (1921), The Organon of the Healing Art (6th ed.), ISBN 0-87983-228-2
  10. 10.0 10.1 10.2 Dynamization and Dilution, Creighton University Department of Pharmacology. Retrieved on 2009-03-24
  11. 11.0 11.1 Homeopathic drugs: No better than placebos?, Washington Post, December 21, 2015. Retrieved on December 22, 2015
  12. Hahnemann S (1833), The Organon of the Healing Art (5th ed.), ISBN 0-87983-228-2
  13. Template:Cite journal
  14. Template:Cite web
  15. 15.0 15.1 15.2 UK Parliamentary Committee Science and Technology Committee - "Evidence Check 2: Homeopathy"
  16. 16.0 16.1 Template:Cite journal
  17. 17.0 17.1 Cucherat, M; MC Haugh & M Gooch et al. (2000), "Evidence of clinical efficacy of homeopathy. A meta-analysis of clinical trials. HMRAG. Homeopathic Medicines Research Advisory Group", European journal of clinical pharmacology 56 (1): 27–33, DOI:10.1007/s002280050716
  18. 18.0 18.1 18.2 Caulfield, Timothy & Suzanne Debow (2005), "A systematic review of how homeopathy is represented in conventional and CAM peer reviewed journals", BMC Complementary and Alternative Medicine 5: 12, DOI:10.1186/1472-6882-5-12
  19. 19.0 19.1 Template:Cite journal
  20. Template:Cite journal
  21. 21.0 21.1 Kleijnen, J; P Knipschild & G Ter Riet (1991), "Clinical trials of homoeopathy", BMJ 302 (6772): 316–23, DOI:10.1136/bmj.302.6772.316
  22. Template:Cite web
  23. Template:Cite book
  24. Template:Cite book
  25. 25.0 25.1 Template:Cite web
  26. Template:Cite news
  27. Template:Cite web
  28. Hemenway, Henry Bixby (1894), "Modern Homeopathy and Medical Science", JAMA: the Journal of the American Medical Association XXII (11): 367, DOI:10.1001/jama.1894.02420900001001
  29. Paracelsus (German-Swiss physician), Encyclopædia Britannica. Retrieved on 2009-03-24
    • Hodgson B (2001), In the Arms of Morpheus: The Tragic History of Morphine, Laudanum and Patent Medicines, Firefly Books, ISBN 1-55297-540-1, at 18
    • Griffin, J. P. (2004), "Venetian treacle and the foundation of medicines regulation", British Journal of Clinical Pharmacology 58 (3): 317–25, DOI:10.1111/j.1365-2125.2004.02147.x
  30. "British Medical Journal", BMJ 1 (533): 283–4, 1871, DOI:10.1136/bmj.1.533.283
  31. 32.0 32.1 Kaufman M (1971), Homeopathy in America: The rise and fall of a medical heresy, The Johns Hopkins University Press, ISBN 978-0-8018-1238-5Template:Page needed
  32. 33.0 33.1 Edzard Ernst; Singh, Simon (2008), Trick or Treatment: The Undeniable Facts about Alternative Medicine, New York: W. W. Norton, ISBN 0-393-06661-4
  33. Lasagna L (1970), The doctors' dilemmas, New York: Collier Books, ISBN 978-0-8369-1669-0, at 33
  34. Template:Cite book
  35. Dean ME (2001), "Homeopathy and "the progress of science"", Hist Sci 39 (125 Pt 3): 255–83. Retrieved on 2009-03-31
  36. Template:Cite book
  37. 38.0 38.1 38.2 Oliver Wendell Holmes, Sr. (1842), Homoeópathy and its kindred delusions: Two lectures delivered before the Boston Society for the Diffusion of Useful Knowledge, Boston as reprinted in Oliver Wendell Holmes, Sr. (1861), Currents and Counter-currents in Medical Science, Ticknor and Fields, OCLC 1544161, at 72–188
  38. The Dental Cosmos: A Monthly Record of Dental Science, Editor Edward C. Kirk, D.D.S., Vol. XXXVI, p. 1031-1032
  39. Template:Cite web
  40. 41.0 41.1 Template:Cite book
  41. Template:Cite book
  42. Hahnemann S (1833), The Organon of the Healing Art (5th ed.), ISBN 0-87983-228-2. Hahnemann S (1842), The Organon of the Healing Art (6th ed.) (published 1921), ISBN 0-87983-228-2
  43. 44.0 44.1 44.2 =History of Homeopathy, Creighton University Department of Pharmacology. Retrieved on 2007-07-23
  44. Template:Cite book
  45. 46.0 46.1 King S, Miasms in homeopathy. Retrieved on 2009-03-25
  46. Ward JW, Taking the History of the Case, Pacific Coast Jnl of Homeopathy, July 1937. Retrieved on 2007-10-22
  47. Cause of Disease in homeopathy, Creighton University Department of Pharmacology. Retrieved on 2007-07-23
  48. Template:Cite book
  49. Hahnemann S (1828), Die chronischen Krankheiten, ihre eigenthümliche Natur und homöopathische Heilung [The chronic diseases, their specific nature and homoeopathic treatment], Dresden and Leipzig: Arnoldische BuchhandlungTemplate:Page needed
  50. Cause of disease, Creighton University School of Medicine. Retrieved on 2009-07-31 Template:Dead link
  51. Hahnemann S (1833), The Organon of the Healing Art (5th ed.), ISBN 0-87983-228-2Template:Page needed Also 6th edition, 1921Template:Page needed
  52. Whorton JC (2004), Nature Cures: The History of Alternative Medicine in America, New York: Oxford University Press US, ISBN 0-19-517162-4, at 18, 52
  53. 54.0 54.1 54.2 54.3 54.4 54.5 54.6 54.7 54.8 54.9 Shelton, Jay W. (2004), Homeopathy: How it Really Works, Amherst, New York: Prometheus Books, ISBN 978-1-59102-109-4
  54. Template:Cite book
  55. Winston J (2006), Homeopathy Timeline, Whole Health Now, ISBN 0-473-05607-0. Retrieved on 2007-07-23
  56. Toufexis A, Cole W, Hallanan DB (25 September 1995), "Is homeopathy good medicine?", Time
  57. Ernst, E. & TJ Kaptchuk (1996), "Homeopathy revisited", Archives of Internal Medicine 156 (19): 2162–4, DOI:10.1001/archinte.156.19.2162
  58. Coulter HL (1973), Divided Legacy, Berkeley: North Atlantic, OCLC 9538442, at II:544–6; III:267–70, 298–305
  59. Death rates in conventional hospitals were typically two- to eight-fold higher than in homeopathic hospitals for patients with these infectious diseases; see Bradford TL (2007), The logic of figures or comparative results of homeopathic and other treatments, Kessinger, ISBN 1-4304-8892-1Template:Page needed
  60. Forbes J (1846), Homeopathy, allopathy and young physic, London
  61. Simpson JY (1853), Homoeopathy, its tenets and tendencies, theoretical, theological and therapeutical, Edinburgh: Sutherland & Knox, at 11
  62. Allen JA, ed. (1867), "Homœopathists vs homœopathy", Chic Med J 24: 268–269
  63. Template:Cite book
  64. Homeopathic Hassle, 1956-08-20
  65. Rader WM (1985-03-01), Riding the coattails of homeopathy's revival, FDA Consumer Magazine
  66. 67.0 67.1 67.2 Template:Cite journal
  67. Template:Cite book
  68. O'Hara M (2002-01-05), A question of health or wealth?, London
  69. Template:Cite news
  70. Template:Cite web
  71. Template:Cite book
  72. Jonas: Mosby's Dictionary of Complementary and Alternative Medicine. (c) 2005, Elsevier
  73. 74.0 74.1 74.2 Bellavite, Paolo; Anita Conforti & Valeria Piasere et al. (2005), "Immunology and Homeopathy. 1. Historical Background", Evidence-Based Complementary and Alternative Medicine 2 (4): 441–52, DOI:10.1093/ecam/neh141
  74. Mathur KN (2003), Prinzipien der homöopathischen Verschreibung: Synopsis weltweiter klinischer Erfahrungen, Georg Thieme Verlag, ISBN 3-8304-9021-6, OCLC 76518035, at 122–123
  75. Lee J, Thompson E (2007), at Northampton, "X-ray drug picture", The Homeopath 26 (2): 43–48, ISSN 0263-3256
  76. Lee J, Thompson E (2007), "Postironium - the vastness of the universe knocks me off my feet", The Homeopath 26 (2): 49–54, ISSN 0263-3256
  77. Shah R, Call for introspection and awakening, Life Force Center. Retrieved on 2007-07-24
  78. Barwell B (2000), "The wo-wo effect", Homoeopathica 20 (3). Retrieved on 2009-04-02
  79. Kayne SB (2006), Homeopathic pharmacy: theory and practice (2 ed.), Elsevier Health Sciences, ISBN 978-0-443-10160-1, at 53
  80. Goldacre, Ben (2008), Bad Science, London: Fourth Estate, ISBN 978-0-00-724019-7
  81. Stephen Barrett, M.D., Homeopathy: The Ultimate Fake. Retrieved on 2011-05-26
  82. Template:Cite web
  83. Template:Cite web
  84. In standard chemistry, this produces a substance with a concentration of 0.01%, measured by the volume-volume percentage method.
  85. Glossary of Homeopathic Terms, Creighton University Department of Pharmacology. Retrieved on 2009-02-15
  86. Smith T (1989), Homeopathic Medicine, Healing Arts Press, at 14–15
  87. Similia similibus curentur (Like cures like), Creighton University Department of Pharmacology. Retrieved on 2007-08-20
  88. http://www.ritecare.com/homeopathic/guide_potency.asp
  89. Template:Cite web
  90. 91.0 91.1 91.2 For further discussion of homeopathic dilutions and the mathematics involved, see Homeopathic dilutions.
  91. 92.0 92.1 Bambridge AD (1989), Homeopathy investigated, Kent, England: Diasozo Trust, ISBN 0-948171-20-0
  92. 93.0 93.1 Andrews P (1990), "Homeopathy and Hinduism", The Watchman Expositor 7 (3)
  93. A 12C solution produced using sodium chloride (also called natrum muriaticum in homeopathy) is the equivalent of dissolving 0.36 mL of table salt, weighing about 0.77 g, into a volume of water the size of the Atlantic Ocean, since the volume of the Atlantic Ocean and its adjacent seas is 3.55×108 km3 or 3.55×1020 L : Emery KO, Uchupi E (1984), The geology of the Atlantic Ocean, Springer, ISBN 0-387-96032-5
  94. The volume of all water on earth is about 1.36×109 km3: Earth's water distribution, United States Geological Survey, 28 August 2006, ISBN 0-07-825402-7
  95. Gleick PH, Water resources, In Encyclopedia of climate and weather, vol. 2, New York: Oxford University Press, 1996, at 817–823
  96. Robert L. Park (2008), Superstition: Belief in the Age of Science, Princeton University Press, ISBN 0-691-13355-7, at 145–146
  97. Fisher, P (2007), "The Memory of Water: a scientific heresy?", Homeopathy 96 (3): 141–2, DOI:10.1016/j.homp.2007.05.008
  98. Template:Cite journal
  99. Wheeler CE (1941), Dr. Hughes: Recollections of some masters of homeopathy, Health through homeopathy
  100. Bodman F (1970), The Richard Hughes memorial lecture, BHJ, at 179–193
  101. HeadOn: Headache drug lacks clinical data, ConsumerReportsHealth.org. Retrieved on 2009-03-25
  102. Analysis of Head On. Retrieved on 2006-07-27
  103. Dantas, F; P Fisher & H Walach et al. (2007), "A systematic review of the quality of homeopathic pathogenetic trials published from 1945 to 1995", Homeopathy 96 (1): 4–16, DOI:10.1016/j.homp.2006.11.005
  104. Kayne SB (2006), Homeopathic pharmacy: theory and practice (2 ed.), Elsevier Health Sciences, ISBN 978-0-443-10160-1, at 52
  105. Template:Cite book
  106. Cassedy JH (1999), American Medicine and Statistical Thinking, 1800–1860, iUniverse, ISBN 978-1-58348-428-9Template:Page needed
  107. Fye WB (1986), "Nitroglycerin: a homeopathic remedy", Circulation 73 (1): 21–9, DOI:10.1161/01.CIR.73.1.21
  108. Hahnemann S (1796), "Versuch über ein neues Prinzip zur Auffindung der Heilkräfte der Arzneisubstanzen, nebst einigen Blicken auf die bisherigen", Hufelands Journal II (3)
  109. Hahnemann S (1805), Fragmenta de Viribus medicamentorum Positivis, Leipzig
  110. Hahnemann S, Stapf E, Gross G, de Brunnow EG (1826–1828), Materia medica pura; sive, Doctrina de medicamentorum viribus in corpore humano sano observatis; e Germanico sermone in Latinum conversa, Dresden: Arnold, OCLC 14840659
  111. Are the principles of Homeopathy scientifically valid?, Creighton University School of Medicine
  112. Stehlin I (1996), Homeopathy: Real medicine or empty promises?, U.S. Food and Drug Administration. Retrieved on 2007-10-01
  113. 114.0 114.1 114.2 Ernst, E (2005), "Is homeopathy a clinically valuable approach?", Trends in Pharmacological Sciences 26 (11): 547–8, DOI:10.1016/j.tips.2005.09.003
  114. Sagar, SM (2007), "Homeopathy: Does a teaspoon of honey help the medicine go down?", Current oncology (Toronto, Ont.) 14 (4): 126–7, DOI:10.3747/co.2007.150
  115. 116.0 116.1 Label data
  116. Template:Cite news
  117. Teut, Michael; JÖrn Dahler & Christoph Schnegg (2008), "A Homoeopathic Proving of Galphimia glauca", Forschende Komplementärmedizin 15 (4): 211–7, DOI:10.1159/000148825
  118. Description of Histaminum Hydrochloricum
  119. Luffa operculata L. COGN Sponge Cucumber
  120. Hoff D, Isopathy, homeoinfo.com. Retrieved on 2009-03-26
  121. Kayne SB (2006), Homeopathic pharmacy: theory and practice (2 ed.), Elsevier Health Sciences, ISBN 978-0-443-10160-1, at 171
  122. Vanhaselen, R (1999), "The relationship between homeopathy and the Dr Bach system of flower remedies: A critical appraisal", British Homoeopathic journal 88 (3): 121–7, DOI:10.1054/homp.1999.0308
  123. Ernst, E (2002), ""Flower remedies": a systematic review of the clinical evidence", Wiener klinische Wochenschrift 114 (23–24): 963–6
  124. Saxton, J (2007), "The diversity of veterinary homeopathy", Homeopathy 96 (1): 3, DOI:10.1016/j.homp.2006.11.010
  125. 126.0 126.1 Hektoen, L (2005), "Review of the current involvement of homeopathy in veterinary practice and research", Veterinary Record 157 (8): 224–9, DOI:10.1136/vr.157.8.224
  126. Template:Cite journal
  127. Template:Cite web
  128. Template:Cite web
  129. Alternative pet remedies: Government clampdown
  130. Template:Cite journal
  131. Template:Cite news
  132. Template:Cite journal
  133. Template:Cite web
  134. Template:Cite news
  135. Template:Cite web
  136. "When to believe the unbelievable", Nature 333 (6176): 787, 1988, DOI:10.1038/333787a0
  137. 138.0 138.1 Template:Cite journal
  138. 139.0 139.1 Sam Jones, "Homeopathy protesters to take 'mass overdose' outside Boots", The Guardian, 29 January 2010
  139. Template:Cite web
  140. Issues surrounding homeopathy, National Health Service. Retrieved on 2011-09-11
  141. Template:Cite book
  142. Template:Cite journal
  143. Template:Cite web
  144. 145.0 145.1 Template:Cite book
  145. Teixeira, J (2007), "Can water possibly have a memory? A sceptical view", Homeopathy 96 (3): 158–62, DOI:10.1016/j.homp.2007.05.001
  146. Teixeira, José; Alenka Luzar & Stéphane Longeville (2006), "Dynamics of hydrogen bonds: how to probe their role in the unusual properties of liquid water", Journal of Physics: Condensed Matter 18 (36): S2353–62, DOI:10.1088/0953-8984/18/36/S09
  147. 148.0 148.1 Weissmann, G (2006), "Homeopathy: Holmes, Hogwarts, and the Prince of Wales", The FASEB Journal 20 (11): 1755–8, DOI:10.1096/fj.06-0901ufm
  148. Anick, David J (2004), "High sensitivity 1H-NMR spectroscopy of homeopathic remedies made in water", BMC Complementary and Alternative Medicine 4: 15, DOI:10.1186/1472-6882-4-15
  149. Template:Cite journal
  150. 151.0 151.1 Levy, G (1986), "Kinetics of drug action: An overview", Journal of Allergy and Clinical Immunology 78 (4 Pt 2): 754–61, DOI:10.1016/0091-6749(86)90057-6
  151. Ernst, E (2007), "Placebo: new insights into an old enigma", Drug Discovery Today 12 (9–10): 413–8, DOI:10.1016/j.drudis.2007.03.007
  152. ISO 3696: 1987
  153. Boyd, Windy A & Phillip L Williams (2003), "Comparison of the sensitivity of three nematode species to copper and their utility in aquatic and soil toxicity test", Environmental Toxicology and Chemistry 22 (11): 2768–74, DOI:10.1897/02-573
  154. Goldoni, Matteo; Maria Vittoria Vettori & Rossella Alinovi et al. (2003), "Models of Neurotoxicity: Extrapolation of Benchmark Doses in Vitro", Risk Analysis 23 (3): 505–14, DOI:10.1111/1539-6924.00331
  155. Yu, Hsin-Su; Wei-Ting Liao & Chee-Yin Chai (2006), "Arsenic Carcinogenesis in the Skin", Journal of Biomedical Science 13 (5): 657–66, DOI:10.1007/s11373-006-9092-8
  156. Template:Cite journal
  157. Template:Cite journal
  158. Template:Cite journal
  159. 160.0 160.1 160.2 Barrett S (28 December 2004), Homeopathy: the ultimate fake, Quackwatch. Retrieved on 2007-07-25
  160. Faziola L, Dynamization and dilution, Creighton University School of Medicine. Retrieved on 2007-07-24
  161. Williams N (26 November 2002), Homeopathy: The test, Horizon (BBC). Retrieved on 2007-01-26 (transcript).
  162. Stossel J (2008), "Homeopathic remedies – can water really remember?", 20/20. Retrieved on 2008-01-22
  163. 164.0 164.1 Linde, K; M Scholz & G Ramirez et al. (1999), "Impact of Study Quality on Outcome in Placebo-Controlled Trials of Homeopathy", Journal of Clinical Epidemiology 52 (7): 631–6, DOI:10.1016/S0895-4356(99)00048-7
  164. Template:Cite journal
  165. Template:Cite journal
  166. Template:Cite journal
  167. Jessica Dacey (14 January 2011), Alternative therapies are put to the test, swissinfo.ch
  168. News in brief: Homeopathic assessment, Times Higher Education, 29 October 2009, timeshighereducation.co.uk
  169. Evidence check: Homeopathy, House of Commons Science and Technology Committee, 20 October 2009, parliament.uk
  170. Evidence Check 2: Homeopathy, Fourth Report of Session 2009–10, House of Commons Science and Technology Committee, 20 October 2009, parliament.uk
  171. Secretary of State for Health Government Response to the Science and Technology Committee report 'Evidence Check 2: Homeopathy', July 2010 ISBN 978-0-10-179142-7
  172. Template:Cite news
  173. Template:Cite news
  174. 175.0 175.1 Template:Cite book
  175. Sterne, J. A C & G Davey Smith (2001), "Sifting the evidence---what's wrong with significance tests? Another comment on the role of statistical methods", BMJ 322 (7280): 226–31, DOI:10.1136/bmj.322.7280.226
  176. Linde, K.; WB Jonas & D Melchart et al. (2001), "The methodological quality of randomized controlled trials of homeopathy, herbal medicines and acupuncture", International Journal of Epidemiology 30 (3): 526–31, DOI:10.1093/ije/30.3.526
  177. Template:Cite journal
  178. Sackett, David L. (1979), "Bias in analytic research", Journal of Chronic Diseases 32 (1–2): 51–63, DOI:10.1016/0021-9681(79)90012-2
  179. Rosenthal, Robert (1979), "The file drawer problem and tolerance for null results", Psychological Bulletin 86 (3): 638–41, DOI:10.1037/0033-2909.86.3.638
  180. Jeffrey D. Scargle (2000), "Publication Bias: The "File-Drawer Problem" in Scientific Inference", Journal of Scientific Exploration 14 (2): 94–106
  181. 182.0 182.1 182.2 Ioannidis, John P. A. (2005), "Why Most Published Research Findings Are False", PLoS Medicine 2 (8): e124, DOI:10.1371/journal.pmed.0020124
  182. 183.0 183.1 183.2 183.3 Goldacre, Ben (2007), "Benefits and risks of homoeopathy", The Lancet 370 (9600): 1672–3, DOI:10.1016/S0140-6736(07)61706-1
  183. Template:Cite journal
  184. Template:Cite journal
  185. 186.0 186.1 Linde, K; N Clausius & G Ramirez et al. (1997), "Are the clinical effects of homoeopathy placebo effects? A meta-analysis of placebo-controlled trials", The Lancet 350 (9081): 834–43, DOI:10.1016/S0140-6736(97)02293-9
  186. The role of plausibility in the evaluation of scientific research, Almeida RM, Rev Saude Publica 2011 Jun;45(3):617-20.
  187. 188.0 188.1 The Lancet (2005), "The end of homoeopathy", The Lancet 366 (9487): 690, DOI:10.1016/S0140-6736(05)67149-8
  188. Template:Cite journal
  189. Milazzo, S; N Russell & E Ernst (2006), "Efficacy of homeopathic therapy in cancer treatment", European Journal of Cancer 42 (3): 282–9, DOI:10.1016/j.ejca.2005.09.025
  190. Template:Cite journal
  191. 192.0 192.1 192.2 Altunc, U.; M. H. Pittler & E. Ernst (2007), "Homeopathy for Childhood and Adolescence Ailments: Systematic Review of Randomized Clinical Trials", Mayo Clinic Proceedings 82 (1): 69–75, DOI:10.4065/82.1.69
  192. Template:Cite journal
  193. Template:Cite journal
  194. Template:Cite journal
  195. McCarney, Robert W; Klaus Linde & Toby J Lasserson (2004), McCarney, Robert W, ed., "Homeopathy for chronic asthma", Cochrane database of systematic reviews (Online) (no. 1): CD000353, DOI:10.1002/14651858.CD000353.pub2
  196. McCarney, Robert W; James Warner & Peter Fisher et al. (2003), McCarney, Robert W, ed., "Homeopathy for dementia", Cochrane database of systematic reviews (Online) (no. 1): CD003803, DOI:10.1002/14651858.CD003803
  197. Template:Cite journal
  198. Smith, Caroline A (2003), Smith, Caroline A, ed., "Homoeopathy for induction of labour", Cochrane database of systematic reviews (Online) (no. 4): CD003399, DOI:10.1002/14651858.CD003399
  199. Template:Cite journal
  200. Long, L & E Ernst (2001), "Homeopathic remedies for the treatment of osteoarthritis: a systematic review", British Homoeopathic journal 90 (1): 37–43, DOI:10.1054/homp.1999.0449
  201. Ernst, E (1999), "Homeopathic prophylaxis of headaches and migraine? A systematic review", Journal of pain and symptom management 18 (5): 353–7, DOI:10.1016/S0885-3924(99)00095-0
  202. Template:Cite journal
  203. Template:Cite journal
  204. Linde, Klaus & Dieter Melchart (1998), "Randomized Controlled Trials of Individualized Homeopathy: A State-of-the-Art Review", The Journal of Alternative and Complementary Medicine 4 (4): 371–88, DOI:10.1089/acm.1998.4.371
  205. Mathie, RT; SM Lloyd & LA Legg et al. (2014), "Randomised placebo-controlled trials of individualised homeopathic treatment: systematic review and meta-analysis", Systematic Reviews 2014 (3): 142, DOI:10.1186/2046-4053-3-142
  206. 207.0 207.1 Template:Cite web
  207. Template:Cite web
  208. Template:Cite web
  209. Template:Cite web
  210. 211.0 211.1 American College of Medical Toxicology & American Academy of Clinical Toxicology (February 2013), Five Things Physicians and Patients Should Question, American College of Medical Toxicology and American Academy of Clinical Toxicology. Retrieved on 5 December 2013, which cites Template:Cite journal
  211. Template:Cite journal
  212. Kolisko L (1959), Physiologischer und physikalischer Nachweis der Wirksamkeit kleinster Entitäten, Stuttgart
  213. Walchli, Chantal; Stephan Baumgartner & Madeleine Bastide (2006), "Effect of Low Doses and High Homeopathic Potencies in Normal and Cancerous Human Lymphocytes: An In Vitro Isopathic Study", Journal of Alternative and Complementary Medicine 12 (5): 421–7, DOI:10.1089/acm.2006.12.421
  214. Walach, H; H Köster & T Hennig et al. (2001), "The effects of homeopathic belladonna 30CH in healthy volunteers ― a randomized, double-blind experiment", Journal of Psychosomatic Research 50 (3): 155–60, DOI:10.1016/S0022-3999(00)00224-5
  215. Hirst, S. J.; N. A. Hayes & J. Burridge et al. (1993), "Human basophil degranulation is not triggered by very dilute antiserum against human IgE", Nature 366 (6455): 525–7, DOI:10.1038/366525a0
  216. Ovelgönne, J. H.; A. W. J. M. Bol & W. C. J. Hop et al. (1992), "Mechanical agitation of very dilute antiserum against IgE has no effect on basophil staining properties", Experientia 48 (5): 504–8, DOI:10.1007/BF01928175
  217. Witt, Claudia M.; Michael Bluth & Stephan Hinderlich et al. (2006), "Does Potentized HgCl2 (Mercurius corrosivus) Affect the Activity of Diastase and -Amylase?", Journal of Alternative and Complementary Medicine 12 (4): 359–65, DOI:10.1089/acm.2006.12.359
  218. Guggisberg, A; S Baumgartner & C Tschopp et al. (2005), "Replication study concerning the effects of homeopathic dilutions of histamine on human basophil degranulation in vitro", Complementary Therapies in Medicine 13 (2): 91–100, DOI:10.1016/j.ctim.2005.04.003
  219. Template:Cite journal
  220. Template:Cite journal
  221. 222.0 222.1 Sullivan W (1988-07-27), Water That Has a Memory? Skeptics Win Second Round. Retrieved on 2007-10-03
  222. Benveniste defended his results by comparing the inquiry to the Salem witch hunts and asserting that "It may be that all of us are wrong in good faith. This is no crime but science as usual and only the future knows."
  223. Template:Cite journal
  224. Template:Cite journal
  225. Template:Cite web
  226. Hilly Janes (September 6, 2008), The Lifestyle 50: The top fifty people who influence the way we eat, exercise and think about ourselves
  227. Memorandum submitted by Edzard Ernst HO 16 to the House of Lords
  228. Boseley S (21 July 2008), at London, "The alternative professor", The Guardian
  229. Complementary therapies: The big con?, London, 2008-04-22. Retrieved on 2010-05-04
  230. Sample I (21 July 2008), at London, "Pharmacists urged to 'tell the truth' about homeopathic remedies", The Guardian
  231. 232.0 232.1 Malik, Imtiaz A. & Sethuraman Gopalan (2002), "Use of CAM results in delay in seeking medical advice for breast cancer", European Journal of Epidemiology 18 (8): 817–22, DOI:10.1023/A:1025343720564
  232. Template:Cite web
  233. Template:Cite web
  234. 235.0 235.1 Template:Cite journal
  235. Template:Cite web
  236. Chakraborti, D; SC Mukherjee & KC Saha et al. (2003), "Arsenic toxicity from homeopathic treatment", Journal of toxicology. Clinical toxicology 41 (7): 963–7, DOI:10.1081/CLT-120026518
  237. Barrett S (4 November 2003), Zicam marketers sued, Homeowatch.org. Retrieved on 2007-10-25
  238. Boodman S (31 January 2006), Paying through the nose, Washington Post. Retrieved on 2007-10-25
  239. Sources:
  240. Matrixx Initiatives, Inc. aka Zicam LLC 6/16/09. Warning letter, FDA, 2009-06-16
  241. Template:Cite journal
  242. Template:Cite web
  243. 244.0 244.1 Template:Cite news
  244. Wahlberg, A (2007), "A quackery with a difference―New medical pluralism and the problem of 'dangerous practitioners' in the United Kingdom", Social Science & Medicine 65 (11): 2307–16, DOI:10.1016/j.socscimed.2007.07.024
  245. National Science Board (2002), Science Fiction and Pseudoscience, Science and engineering indicators 2002, Arlington, Virginia: National Science Foundation Directorate for Social, Behavioral and Economic Sciences
  246. Atwood, K. C. (2003), ""Neurocranial Restructuring" and Homeopathy, Neither Complementary nor Alternative", Archives of Otolaryngology - Head and Neck Surgery 129 (12): 1356–7, DOI:10.1001/archotol.129.12.1356
  247. Ndububa, VI (2007), "Medical quackery in Nigeria; why the silence?", Nigerian journal of medicine 16 (4): 312–7, DOI:10.4314/njm.v16i4.37328
  248. Ernst, E. & MH Pittler (1998), "Efficacy of Homeopathic Arnica: A Systematic Review of Placebo-Controlled Clinical Trials", Archives of Surgery 133 (11): 1187–90, DOI:10.1001/archsurg.133.11.1187
  249. Template:Cite news
  250. 251.0 251.1 Ernst, E & AR White (1995), "Homoeopathy and immunization", The British journal of general practice 45 (400): 629–30
  251. 252.0 252.1 252.2 Jones M (2006-07-14), "Malaria advice 'risks lives'", Newsnight. Retrieved on 2009-03-24
  252. Case of Baby Gloria, who died in 2002:
  253. 254.0 254.1 Alastair Neil Hope, State Coroner, Coroner's inquest into the death of Penelope Dingle. Ref No: 17/10
  254. Schmukler AV (2006), Homeopathy: An A to Z Home Handbook, Llewellyn Worldwide, ISBN 978-0-7387-0873-7, at 16
  255. Ernst, E. (1997), "The attitude against immunisation within some branches of complementary medicine", European Journal of Pediatrics 156 (7): 513–5, DOI:10.1007/s004310050650
  256. Ernst, E (2001), "Rise in popularity of complementary and alternative medicine: reasons and consequences for vaccination", Vaccine 20: S90–3; discussion S89, DOI:10.1016/S0264-410X(01)00290-0
  257. Pray WS (1996), "The Challenge to Professionalism Presented by Homeopathy", American Journal of Pharmaceutical Education 60: 198–204
  258. Pray WS (1992), "A challenge to the credibility of homeopathy", Am J Pain Management (no. 2): 63–71
  259. English, J (1992), "The issue of immunization", British Homoeopathic journal 81 (4): 161–3, DOI:10.1016/S0007-0785(05)80171-1
  260. 261.0 261.1 Jha A (14 July 2006), at London, "Homeopaths 'endangering lives' by offering malaria remedies", The Guardian
  261. 262.0 262.1 Starr, M. (2000), "Malaria affects children and pregnant women most", BMJ 321 (7271): 1288, DOI:10.1136/bmj.321.7271.1288
  262. Template:Cite web
  263. Bunyan N (2007-03-22), Patient died after being told to stop heart medicine, London. Retrieved on 2007-10-15
  264. Fitness To Practise panel hearing on Dr Marisa Viegas, General Medical Council (via archive.org), June 2007. Retrieved on 2009-01-25
  265. Template:Cite web
  266. Birnbaum NR, Goldschmidt RH, Buffett WO (1999), "Resolving the common clinical dilemmas of syphilis", Am Fam Physician 59 (8): 2233–40, 2245–6
  267. Pray WS (2006), "Ethical, scientific, and educational concerns with unproven medications", Am J Pharm Educ 70 (6): 141, DOI:10.5688/aj7006141
  268. Baum, Michael & Edzard Ernst (2009), "Should We Maintain an Open Mind about Homeopathy?", The American Journal of Medicine 122 (11): 973–4, DOI:10.1016/j.amjmed.2009.03.038
  269. Template:Cite news
  270. Template:Cite news
  271. 272.0 272.1 272.2 Legal Status of Traditional Medicine and Complementary/Alternative Medicine: A Worldwide Review, World Health Organization, 2001, ISBN 978-92-4-154548-8
  272. Hauptverband der österreichischen Sozialversicherungsträger (31 March 2004), Liste nicht erstattungsfähiger Arzneimittelkategorien gemäß § 351c Abs. 2 ASVG (List of treatments not reimbursable by social service providers in Austria)
  273. Template:Cite court
  274. Dacey J (14 January 2011), Alternative therapies are put to the test, swissinfo.ch. Retrieved on 2011-01-17
  275. Alternative System of Health Care, Government of India. Retrieved on 2010-01-15
  276. Template:Cite news
  277. http://www.homoeoscan.com/2015/06/Kerala-AYUSH-department-Final-nod.html
  278. Template:Cite web
  279. The Homoeopathy Central Council Act, 1973, s. 15 and Sch. II, Central Council of Homeopathy, India. Retrieved on 2010-01-18
  280. Template:Cite web
  281. Template:Cite web
  282. Template:Cite web
  283. Template:Cite web
  284. Template:Cite web
  285. Template:Cite web
  286. Template:Cite web
  287. Template:Cite web
  288. Template:Cite web
  289. Template:Cite web
  290. Template:Cite web
  291. Template:Cite web
  292. Template:Cite web
  293. Template:Cite web
  294. Template:Cite web
  295. Template:Cite web
  296. Template:Cite web
  297. Template:Cite web
  298. Template:Cite journal
  299. 300.0 300.1 300.2 Template:Cite web
  300. Template:Cite journal
  301. Template:Cite web

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